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<title>Staphylococcus pseudintermedius</title>

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Staphylococcus pseudintermedius

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<th colspan="2" style="color:inherit; text-align: center; background-color: rgb(220,235,245)">Staphylococcus pseudintermedius

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<th colspan="2" style="color:inherit; min-width:15em; text-align: center; background-color: rgb(220,235,245)"><a href="Taxonomy_(biology)" title="Taxonomy (biology)">Scientific classification</a>

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<td>Domain:

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<td><a href="Bacteria" title="Bacteria">Bacteria</a>

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<td>Kingdom:

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<td><a href="Bacillati" title="Bacillati">Bacillati</a>

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<td>Phylum:

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<td><a href="Bacillota" title="Bacillota">Bacillota</a>

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<td>Class:

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<td><a href="Bacilli" title="Bacilli">Bacilli</a>

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<td>Order:

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<td><a href="Bacillales" title="Bacillales">Bacillales</a>

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<td>Family:

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<td><a href="Staphylococcaceae" title="Staphylococcaceae">Staphylococcaceae</a>

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<td>Genus:

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<td><a href="Staphylococcus" title="Staphylococcus">Staphylococcus</a>

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<td>Species:

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<td><div style="display:inline" class="species">S. pseudintermedius</div>

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<th colspan="2" style="color:inherit; text-align: center; background-color: rgb(220,235,245)"><a href="Binomial_nomenclature" title="Binomial nomenclature">Binomial name</a>

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<td colspan="2" style="text-align: center">Staphylococcus pseudintermedius <div style="font-size: 85%;">Devriese et al. 2005</div>

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Staphylococcus pseudintermedius is a gram-positive <a href="Coccus" class="mw-redirect" title="Coccus">spherically shaped</a> bacterium of the genus <a href="Staphylococcus" title="Staphylococcus">Staphylococcus</a><a href="#cite_note-González-Martín_2020-1">[1]</a> found worldwide.<a href="#cite_note-Pires_Dos_Santos_2016-2">[2]</a> It is primarily a <a href="Pathogen" title="Pathogen">pathogen</a> for domestic animals,<a href="#cite_note-pmid21038805-3">[3]</a><a href="#cite_note-Feuer2024-4">[4]</a> but has been known to affect humans as well.<a href="#cite_note-pmid27241371-5">[5]</a> S. pseudintermedius is an opportunistic pathogen that secretes immune-modulating virulence factors, has many adhesion factors, and the potential to create <a href="Biofilm" title="Biofilm">biofilms</a>, all of which help to determine the pathogenicity of the bacterium.<a href="#cite_note-Pompilio_2015-6">[6]</a><a href="#cite_note-Garbacz_2013-7">[7]</a> Diagnoses of S. pseudintermedius have traditionally been made using cytology, plating, and biochemical tests.<a href="#cite_note-Becker_2011-8">[8]</a> More recently, molecular technologies like <a href="Matrix-assisted_laser_desorption/ionization" title="Matrix-assisted laser desorption/ionization">MALDI-TOF</a>, <a href="Nucleic_acid_hybridization" title="Nucleic acid hybridization">DNA hybridization</a> and <a href="Polymerase_chain_reaction" title="Polymerase chain reaction">PCR</a> have become preferred over biochemical tests for their more rapid and accurate identifications.<a href="#cite_note-Decristophoris_2011-9">[9]</a><a href="#cite_note-Murugaiyan_2014-10">[10]</a> This includes the identification and diagnosis of antibiotic resistant strains.

<div class="mw-heading mw-heading2"><h2 id="Morphology_and_classification">Morphology and classification</h2></div>

Staphylococci spp. are a genus of gram positive cocci of 0.5 - 1 μm diameter. Staphylococcus pseudintermedius is a non-motile and non-spore forming, facultatively anaerobic bacterium. It appears primarily as grape-like clusters morphologically, but can also be seen as individual or paired cocci.<a href="#cite_note-11">[11]</a> This clustered configuration, as well as the positive catalase test, differentiates Staphylococcus spp. from Streptococcus spp., which manifests in chains. Due to its ability to clot blood, S. pseudintermedius is subcategorized into a group of coagulase positive (CoPS) staphylococci. CoPS strains typically express more virulence factors. This CoPS characteristic is a contributing factor to its biochemical similarities to S.aureus.<a href="#cite_note-Chanchaithong_175–181-12">[12]</a>

Staphylococcal organisms belong to the <a href="Staphylococcaceae" title="Staphylococcaceae">Staphylococcaceae</a> family. S. aureus and Staphylococcus epidermidis are other notable species which fall into the same genus as S. pseudintermedius, under this taxonomic categorization.<a href="#cite_note-Chanchaithong_175–181-12">[12]</a> S. pseudintermedius, Staphylococcus intermedius, and Staphylococcus delphini are largely phenotypically indiscriminate and therefore comprise the 'Staphylococcus intermedius group' of organisms.<a href="#cite_note-Sasaki_2007-13">[13]</a> Biochemical properties of these three organisms place them as an intermediate between S. aureus and S. epidermidis.<a href="#cite_note-Bond_2012-14">[14]</a>

Staphylococcus pseudintermedius was first identified as a novel species in 2005 using 16S rRNA gene sequencing of the tRNA intergenic length polymorphisms of the AJ780976 gene loci.<a href="#cite_note-Devriese_2005-15">[15]</a><a href="#cite_note-16">[16]</a><a href="#cite_note-17">[17]</a> Differing strains of S. pseudintermedius, LMG 22219 - LMG 22222, have been identified in various species: cat, horse, dog, and parrot, respectively.<a href="#cite_note-Devriese_2005-15">[15]</a> These strains comprise a Staphylococcal species that is distinct from other species within the genus, as distinguished by DNA hybridizations of genome sequences.<a href="#cite_note-Sasaki_2007-13">[13]</a> Previously, many S. pseudintermedius infections or isolates were identified as Staphylococcus intermedius, before its identification as a distinct species.<a href="#cite_note-Bond_2012-14">[14]</a>

Isolation of S. pseudintermedius from the skin and mucosa of healthy canine can be between 20 and 90%, with these frequencies being reduced in healthy felines to 5-45%. It is the most commonly identified Staphylococcus spp. in these animal species.<a href="#cite_note-Bond_2012-14">[14]</a> S. pseudintermedius is classified as a biocontainment risk level 2 organism due to its moderately pathogenic characteristics.<a href="#cite_note-18">[18]</a>

<div class="mw-heading mw-heading2"><h2 id="Diagnosis">Diagnosis</h2></div>

<div class="mw-heading mw-heading3"><h3 id="Cytology">Cytology</h3></div>

Using the <a href="Gram_stain" title="Gram stain">Gram stain</a> technique, <a href="Staphylococcus" title="Staphylococcus">staphylococci</a> are easily identified by their clumped, gram-positive, coccus morphology.<a href="#cite_note-Becker_2011-8">[8]</a> Slides can be prepared directly using a patient swab, which lends to convenience in the clinic or classroom. However, given that S. pseudintermedius is prevalent within the normal <a href="Microbiota" title="Microbiota">microbiota</a> of numerous species, it is better identified as the agent of disease when a corresponding immune reaction is also observed.<a href="#cite_note-Becker_2011-8">[8]</a> Where available, the need to identify immune reactors can be avoided by first inoculating the sample onto differential agar like Staphylococcus Medium 110,<a href="#cite_note-19">[19]</a> which inhibit the growth of non-staphylococcal bacteria. Cytology alone does not allow for the differentiation between different species in the Staphylococcus genus.

<div class="mw-heading mw-heading3"><h3 id="Plating">Plating</h3></div>

When plated on sheep or bovine <a href="Agar_plate" title="Agar plate">blood agar</a>, S. pseudintermedius displays incomplete ß-hemolysis.<a href="#cite_note-Bannoehr_2012-20">[20]</a><a href="#cite_note-Becker_2011-8">[8]</a> Colonies of S. pseudintermedius on sheep agar are described as medium in size and non-pigmented or grey-white.<a href="#cite_note-Bannoehr_2012-20">[20]</a><a href="#cite_note-Becker_2011-8">[8]</a> This can be useful for differentiating S. pseudintermedius from coagulase-negative staphylococci, and from <a href="Staphylococcus_aureus" title="Staphylococcus aureus">S. aureus</a> which tends to be yellow and displays more variable hemolytic patterns on agar.<a href="#cite_note-Bannoehr_2012-20">[20]</a><a href="#cite_note-Becker_2011-8">[8]</a> S. pseudintermedius colonies are not hemolytic on equine blood agar.<a href="#cite_note-Bannoehr_2012-20">[20]</a><a href="#cite_note-Becker_2011-8">[8]</a> While plating may help differentiate species, biochemical or DNA testing may be necessary.<a href="#cite_note-21">[21]</a>

<div class="mw-heading mw-heading3"><h3 id="Biochemical_tests">Biochemical tests</h3></div>

Historically, biochemical tests have been an important tool used to discriminate between Staphylococcus species.<a href="#cite_note-Bannoehr_2012-20">[20]</a><a href="#cite_note-Becker_2011-8">[8]</a> Tests used to identify S. pseudintermedius specifically include DNase,<a href="#cite_note-Sasaki_2007-13">[13]</a> hyaluronidase,<a href="#cite_note-22">[22]</a> coagulase, catalase, and acetoin production tests, amongst others.<a href="#cite_note-Becker_2011-8">[8]</a> It can still be difficult to differentiate between members of the S. intermedius group using these methods alone; in veterinary medicine, such diagnoses have relied on the assumption that S. pseudintermedius is the only known member of this group to infect canine skin.<a href="#cite_note-Bannoehr_2012-20">[20]</a> More recently, studies using molecular identification methods have found that different S. pseudintermedius strains harbor more phenotypic diversity than previously thought.<a href="#cite_note-Decristophoris_2011-9">[9]</a><a href="#cite_note-Murugaiyan_2014-10">[10]</a><a href="#cite_note-Sasaki_2007-13">[13]</a> It has been speculated that these differences have led to underestimation of the importance of S. pseudintermedius in human skin infections.<a href="#cite_note-Börjesson_2015-23">[23]</a> Further, for this reason, S. pseudintermedius is no longer considered to be reliably identifiable using commercially available biochemical tests alone.<a href="#cite_note-Bannoehr_2012-20">[20]</a><a href="#cite_note-Decristophoris_2011-9">[9]</a><a href="#cite_note-Börjesson_2015-23">[23]</a> More sensitive methods like MALDI-TOF have therefore since become preferred.<a href="#cite_note-Decristophoris_2011-9">[9]</a><a href="#cite_note-Murugaiyan_2014-10">[10]</a><a href="#cite_note-Sasaki_2007-13">[13]</a>

<div class="mw-heading mw-heading3"><h3 id="Identification_of_methicillin_resistance">Identification of methicillin resistance</h3></div>

Molecular methods, like MALDI-TOF <a href="#cite_note-24">[24]</a> and qPCR primers,<a href="#cite_note-25">[25]</a> are the gold standard for accurately identifying the presence of the mecA gene, which confers resistance to beta-lactam drugs. However, methicillin resistance can still be identified reliably using biochemical or phenotypic methods, such as disc diffusion. Although cefoxitin disks have been used,<a href="#cite_note-26">[26]</a> oxacillin disks are considered to be much more sensitive, and thus a more accurate method for predicting methicillin resistance in S. pseudintermedius strains.<a href="#cite_note-27">[27]</a><a href="#cite_note-28">[28]</a>

<div class="mw-heading mw-heading2"><h2 id="Epidemiology">Epidemiology</h2></div>

In dogs, S. pseudintermedius is normally found on the microbiota of the skin.<a href="#cite_note-29">[29]</a><a href="#cite_note-Somayaji_2016-30">[30]</a> The presence of S. pseudintermediushas been observed in higher amounts on dogs that suffer from atopic dermatitis.<a href="#cite_note-Somayaji_2016-30">[30]</a> It is also one of the leading causes of bacterial skin and soft tissue infections,<a href="#cite_note-Gagetti_2019-31">[31]</a><a href="#cite_note-Somayaji_2016-30">[30]</a> such as <a href="Pyoderma" title="Pyoderma">pyoderma</a>, <a href="Urinary_tract_infection" title="Urinary tract infection">urinary tract infections</a>,<a href="#cite_note-32">[32]</a> and surgical site infections.<a href="#cite_note-Gagetti_2019-31">[31]</a><a href="#cite_note-Pires_Dos_Santos_2016-2">[2]</a> It is also known to infect cats, although not as common.<a href="#cite_note-33">[33]</a> It is transferred by animal-animal contact, and some dog-human <a href="Zoonosis" title="Zoonosis">zoonoses</a> have also been reported.<a href="#cite_note-Bannoehr_2012-20">[20]</a> Transmission is done either <a href="Vertically_transmitted_infection" title="Vertically transmitted infection">vertically</a> or <a href="Horizontal_transmission" title="Horizontal transmission">horizontally</a>.<a href="#cite_note-Bannoehr_2012-20">[20]</a> The overall prevalence of S. pseudintermedius in small animals is increasing every year,<a href="#cite_note-Eckholm_2013-34">[34]</a> specifically in small animals worldwide.<a href="#cite_note-Gagetti_2019-31">[31]</a>

Staphylococcus pseudintermedius is becoming a threat due to its <a href="Homogeneity_and_heterogeneity" title="Homogeneity and heterogeneity">heterogeneous</a> qualities<a href="#cite_note-pmid21721415-35">[35]</a> and multi-drug resistance <a href="Phenotype" title="Phenotype">phenotype</a>.<a href="#cite_note-Pires_Dos_Santos_2016-2">[2]</a><a href="#cite_note-Eckholm_2013-34">[34]</a> Methicillin-resistant S. pseudintermedius (MRSP) has five major clonal complex (CC) lineages,<a href="#cite_note-Pires_Dos_Santos_2016-2">[2]</a> each with their own unique traits regarding genetic diversity, geographical distribution and <a href="Antimicrobial_resistance" title="Antimicrobial resistance">antimicrobial resistance</a>.<a href="#cite_note-36">[36]</a><a href="#cite_note-Pires_Dos_Santos_2016-2">[2]</a> The majority of all MRSP isolates were found in Europe and Asia, with North America, South America, and Oceania contributing only a small portion.<a href="#cite_note-Pires_Dos_Santos_2016-2">[2]</a> The CC71 and CC258 lineages were mostly seen in Europe, CC68 was mostly seen in North America, and CC45 and CC112 seen in Asia.<a href="#cite_note-Pires_Dos_Santos_2016-2">[2]</a> The top three antimicrobials worldwide that MRSP is found to be resistant to are <a href="Erythromycin" title="Erythromycin">erythromycin</a>, <a href="Clindamycin" title="Clindamycin">clindamycin</a>, and <a href="Tetracycline" title="Tetracycline">tetracycline</a>.<a href="#cite_note-Pires_Dos_Santos_2016-2">[2]</a>

When looking at the epidemiology of the S. intermedius group (SIG), which includes S. pseudintermedius, S. intermedius, and S. delphini, it is noted that in humans most of the recorded cases were above the age of 50, <a href="Diabetes" title="Diabetes">diabetic</a>, and/or <a href="Immunocompromised" class="mw-redirect" title="Immunocompromised">immunocompromised</a> in some way.<a href="#cite_note-Yarbrough_2018-37">[37]</a> Most of the cultures came from wound sites and respiratory specimens.<a href="#cite_note-Yarbrough_2018-37">[37]</a> S. pseudintermedius is not normally found within the microbiota of humans.<a href="#cite_note-Bannoehr_2012-20">[20]</a> Humans that work in close proximity to animals are at higher risk of S. pseudintermedius infections, such as <a href="Veterinarian" title="Veterinarian">veterinarians</a>, animal trainers, and <a href="Zookeeper" title="Zookeeper">zookeepers</a>.<a href="#cite_note-Bannoehr_2012-20">[20]</a> Although the risk of pet owners becoming infected by their pets is low, there have been reported cases.<a href="#cite_note-Kmieciak_2018-38">[38]</a>

<div class="mw-heading mw-heading2"><h2 id="Pathogenicity_and_virulence">Pathogenicity and virulence</h2></div>

As previously described, S. pseudintermedius, an opportunistic pathogen, is a part of the normal microbiome of the skin and mucous membranes in animals.<a href="#cite_note-Bannoehr_2012-20">[20]</a> Animals acquire this bacterium through vertical transmission with transfer of S. pseudintermedius from the mother's vaginal mucous membrane to their offspring during birth.<a href="#cite_note-Bannoehr_2012-20">[20]</a> A compromised immune system or tissue injury allows this bacterium to push past host defences leading to infection.<a href="#cite_note-Bannoehr_2012-20">[20]</a> This results in clinical manifestations such as purulent dermatitis, otitis externa, conjunctivitis,<a href="#cite_note-Garbacz_2013-7">[7]</a> urinary tract infections,<a href="#cite_note-Bannoehr_2012-20">[20]</a> and post-operative infections.<a href="#cite_note-Pompilio_2015-6">[6]</a> Disease is most commonly seen in dogs and cats<a href="#cite_note-Bannoehr_2012-20">[20]</a><a href="#cite_note-Pompilio_2015-6">[6]</a> with canine pyoderma being the most notable manifestation of S. pseudintermedius.<a href="#cite_note-Bajwa_2016-39">[39]</a>

The virulence of S. pseudintermedius is an area of on going research and has many unknowns.<a href="#cite_note-Fitzgerald_2009-40">[40]</a> The virulence factors carried by S. pseudintermedius vary between strains and do not determine if it will cause an infection. Rather, infection is a result of an animal's immune status,<a href="#cite_note-González-Martín_2020-1">[1]</a> environment, and genetics.<a href="#cite_note-Bajwa_2016-39">[39]</a>

Numerous virulence factors such as enzymes, toxins, and binding proteins have been associated with different S. pseudintermedius strains. These include <a href="Protease" title="Protease">proteases</a>, thermonucleases, <a href="Coagulase" title="Coagulase">coagulases</a>,<a href="#cite_note-Fitzgerald_2009-40">[40]</a> DNAase, <a href="Lipase" title="Lipase">lipase</a>, <a href="Hemolysin" title="Hemolysin">hemolysin</a>, clumping factor, leukotoxin, <a href="Enterotoxin" title="Enterotoxin">enterotoxin</a>,<a href="#cite_note-Pompilio_2015-6">[6]</a> protein A, and exfoliative toxin.<a href="#cite_note-Fitzgerald_2009-40">[40]</a>

<div class="mw-heading mw-heading3"><h3 id="Immune-modulating_virulence_factors">Immune-modulating virulence factors</h3></div>

Haemolysins, leukotoxins, exfoliative toxins, and enterotoxins are secreted<a href="#cite_note-Bannoehr_2012-20">[20]</a> from the bacteria to modulate the host's immune response.<a href="#cite_note-Garbacz_2013-7">[7]</a>

The pore-forming cytotoxins, α-hemolysin and β-hemolysin, lyse erythrocytes of sheep and rabbits.<a href="#cite_note-Bannoehr_2012-20">[20]</a><a href="#cite_note-González-Martín_2020-1">[1]</a> Leukotoxin destroys host <a href="Leukocytes" class="mw-redirect" title="Leukocytes">leukocytes</a> and causes tissue necrosis.<a href="#cite_note-Garbacz_2013-7">[7]</a> Exfoliative toxin is responsible for the majority of symptoms seen in canine pyoderma<a href="#cite_note-Fitzgerald_2009-40">[40]</a> and otitis i.e. skin exfoliation and crusting.<a href="#cite_note-Garbacz_2013-7">[7]</a> Exfoliative toxin causes vesicle formation and erosion in epithelial cells resulting in splitting of the skin.<a href="#cite_note-González-Martín_2020-1">[1]</a> Super-<a href="Antigen" title="Antigen">antigens</a> such as enterotoxins activate host immune cells causing <a href="T_cell" title="T cell">T cell</a> proliferation and <a href="Cytokine" title="Cytokine">cytokine</a> release.<a href="#cite_note-Garbacz_2013-7">[7]</a> This virulence factor induces vomiting and has been associated with food poisoning in humans.<a href="#cite_note-Garbacz_2013-7">[7]</a> Protein A, an immunoglobulin binding protein, has been found on the surface of S. pseudintermedius.<a href="#cite_note-González-Martín_2020-1">[1]</a> Protein A attaches to the Fc region of host <a href="Antibody" title="Antibody">antibodies</a>, rendering them useless. Without the Fc region, the host immune system cannot recognize that antibody; the <a href="Complement_system" title="Complement system">complement system</a> cannot be activated and <a href="Phagocyte" title="Phagocyte">phagocytes</a> cannot destroy the bacteria.<a href="#cite_note-Garbacz_2013-7">[7]</a><a href="#cite_note-Fitzgerald_2009-40">[40]</a>

<div class="mw-heading mw-heading3"><h3 id="Virulence_factors_for_dissemination_and_adhesion">Virulence factors for dissemination and adhesion</h3></div>

The previously mentioned protein A, as well as clumping factor, are surface proteins that allow the bacteria to bind to host cells.<a href="#cite_note-Bannoehr_2012-20">[20]</a><a href="#cite_note-Garbacz_2013-7">[7]</a> S. pseudintermedius has been found to produce <a href="Biofilm" title="Biofilm">biofilms</a>, an extracellular matrix of protein, DNA, and polysaccharide, which aids the bacteria in avoiding the host immune system and resisting drugs.<a href="#cite_note-Pompilio_2015-6">[6]</a> Biofilms allow the bacteria to persist on medical equipment even after disinfection and adhere to host cells, a component of chronic infections.<a href="#cite_note-Pompilio_2015-6">[6]</a> Fragments of a biofilm can break off and disseminate to other sites in the body, spreading infection.<a href="#cite_note-Garbacz_2013-7">[7]</a> <a href="Quorum_sensing" title="Quorum sensing">Quorum sensing</a>, a mechanism that coordinates the bacteria's colonization efforts, has been reported in some strains.<a href="#cite_note-Bannoehr_2012-20">[20]</a> Coagulase, lipase, and DNAase produced by the bacteria also aid in its dissemination throughout the host body.<a href="#cite_note-Garbacz_2013-7">[7]</a>

<div class="mw-heading mw-heading2"><h2 id="Zoonosis">Zoonosis</h2></div>

Staphyloccus pseudintermedius has zoonotic potential as it has been found in humans that live with companion animals in the same household.<a href="#cite_note-Kmieciak_2018-38">[38]</a><a href="#cite_note-Somayaji_2016-30">[30]</a><a href="#cite_note-Bannoehr_2012-20">[20]</a> S. pseudintermedius is not a normal commensal bacterium found in humans, however it is capable of adapting to the human microbiota and has become increasingly more common.<a href="#cite_note-Bannoehr_2012-20">[20]</a> People at the highest risk for contracting this pathogen are pet owners and veterinarians due to their higher contact with dogs and to a lesser extent cats.<a href="#cite_note-Starlander_2014-41">[41]</a> The most common colonization site in the human body is within the nasal cavity and from here, the bacteria can cause infections.<a href="#cite_note-Stegmann_2010-42">[42]</a><a href="#cite_note-Merck_Manual-43">[43]</a> S. pseudintermedius infections in a human host have been known to cause endocarditis, post-surgical infections, inflammation of the nasal cavity (<a href="Sinusitis" title="Sinusitis">rhinosinusitis</a>) and catheter-related bacteremia.<a href="#cite_note-Pompilio_2015-6">[6]</a> Staphyloccus pseudintermedius becomes established in a human wound, it has the ability to form antibiotic resistance biofilms.<a href="#cite_note-Pompilio_2015-6">[6]</a> Mechanisms of biofilm resistance of S. pseudintermedius are likely multifactorial and may help to establish infections in humans.<a href="#cite_note-Pompilio_2015-6">[6]</a>

<div class="mw-heading mw-heading3"><h3 id="Resistance_in_humans">Resistance in humans</h3></div>

There is an increasing prevalence of antibiotic resistance in S. pseudintermedius, specifically to <a href="Methicillin" title="Methicillin">methicillin</a>, which makes it challenging to treat in humans.<a href="#cite_note-Paul_2011-44">[44]</a><a href="#cite_note-Stegmann_2010-42">[42]</a><a href="#cite_note-Starlander_2014-41">[41]</a> Veterinary dermatologists are exposed to animals with skin and soft infections that commonly possess MRSP (methicillin‐resistant Staphylococcus pseudintermedius). Veterinarians have been found to be colonized with MRSP but not MSSP (methicillin‐susceptible S. pseudintermedius).<a href="#cite_note-Bannoehr_2012-20">[20]</a><a href="#cite_note-Paul_2011-44">[44]</a> Treatment of human MRSP infections is done with antibiotics and these should not be used for treatment in animals.<a href="#cite_note-Stegmann_2010-42">[42]</a> Oral antimicrobial treatment for active infection is commonly done with the use of <a href="Mupirocin" title="Mupirocin">mupirocin</a>, <a href="Linezolid" title="Linezolid">linezolid</a>, <a href="Quinupristin/dalfopristin" title="Quinupristin/dalfopristin">quinupristin</a>, <a href="Rifampicin" title="Rifampicin">rifampicin</a> or <a href="Vancomycin" title="Vancomycin">vancomyocin</a> are possible treatments.<a href="#cite_note-Stegmann_2010-42">[42]</a><a href="#cite_note-Merck_Manual-43">[43]</a> Hand washing, sterilizing equipment and hygiene practices should be implemented to decrease the spread of Staphylococcus infections.<a href="#cite_note-Bannoehr_2012-20">[20]</a><a href="#cite_note-Merck_Manual-43">[43]</a>

<div class="mw-heading mw-heading2"><h2 id="References">References</h2></div>

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</style><cite id="CITEREFGonzález-MartínCorberaSuárez-BonnetTejedor-Junco2020" class="citation journal cs1">González-Martín M, Corbera JA, Suárez-Bonnet A, Tejedor-Junco MT (December 2020). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7178840">"Staphylococcus aureus"</a>. The Veterinary Quarterly. 40 (1): 118–131. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1080%2F01652176.2020.1748253">10.1080/01652176.2020.1748253</a>. <a href="PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7178840">7178840</a>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/32223696">32223696</a>.</cite>

</li>

<li id="cite_note-Pires_Dos_Santos_2016-2">^ <a href="#cite_ref-Pires_Dos_Santos_2016_2-0">a</a> <a href="#cite_ref-Pires_Dos_Santos_2016_2-1">b</a> <a href="#cite_ref-Pires_Dos_Santos_2016_2-2">c</a> <a href="#cite_ref-Pires_Dos_Santos_2016_2-3">d</a> <a href="#cite_ref-Pires_Dos_Santos_2016_2-4">e</a> <a href="#cite_ref-Pires_Dos_Santos_2016_2-5">f</a> <a href="#cite_ref-Pires_Dos_Santos_2016_2-6">g</a> <a href="#cite_ref-Pires_Dos_Santos_2016_2-7">h</a> <cite id="CITEREFPires_Dos_SantosDamborgMoodleyGuardabassi2016" class="citation journal cs1">Pires Dos Santos T, Damborg P, Moodley A, Guardabassi L (2016). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5067483">"Staphylococcus pseudintermedius: Inference of Population Structure from Multilocus Sequence Typing Data"</a>. Frontiers in Microbiology. 7: 1599. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.3389%2Ffmicb.2016.01599">10.3389/fmicb.2016.01599</a>. <a href="PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5067483">5067483</a>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/27803691">27803691</a>.</cite>

</li>

<li id="cite_note-pmid21038805-3"><a href="#cite_ref-pmid21038805_3-0">^</a> <cite id="CITEREFVinczePaaschWaltherRuscher2010" class="citation journal cs1">Vincze S, Paasch A, Walther B, Ruscher C, Lübke-Becker A, Wieler LH, Barbara K (2010). "Multidrug- and methicillin resistant Staphylococcus pseudintermedius as a cause of canine pyoderma: a case report". Berliner und Munchener Tierarztliche Wochenschrift. 123 (9–10): 353–8. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/21038805">21038805</a>.</cite>

</li>

<li id="cite_note-Feuer2024-4"><a href="#cite_ref-Feuer2024_4-0">^</a> <cite id="CITEREFFeuerFrenzerMerleBäumer2024" class="citation journal cs1">Feuer, Leonie; Frenzer, Stefanie Katharina; Merle, Roswitha; Bäumer, Wolfgang; Lübke-Becker, Antina; Klein, Babette; Bartel, Alexander (2024-07-17). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11273960">"Comparative Analysis of Methicillin-Resistant Staphylococcus pseudintermedius Prevalence and Resistance Patterns in Canine and Feline Clinical Samples: Insights from a Three-Year Study in Germany"</a>. Antibiotics. 13 (7): 660. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.3390%2Fantibiotics13070660">10.3390/antibiotics13070660</a>. <a href="ISSN_(identifier)" class="mw-redirect" title="ISSN (identifier)">ISSN</a> <a rel="nofollow" class="external text" href="https://search.worldcat.org/issn/2079-6382">2079-6382</a>. <a href="PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11273960">11273960</a>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/39061342">39061342</a>.</cite>

</li>

<li id="cite_note-pmid27241371-5"><a href="#cite_ref-pmid27241371_5-0">^</a> <cite id="CITEREFSomayajiPriyanthaRubinChurch2016" class="citation journal cs1">Somayaji R, Priyantha MA, Rubin JE, Church D (August 2016). "Human infections due to Staphylococcus pseudintermedius, an emerging zoonosis of canine origin: report of 24 cases". Diagnostic Microbiology and Infectious Disease. 85 (4): 471–6. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.diagmicrobio.2016.05.008">10.1016/j.diagmicrobio.2016.05.008</a>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/27241371">27241371</a>.</cite>

</li>

<li id="cite_note-Pompilio_2015-6">^ <a href="#cite_ref-Pompilio_2015_6-0">a</a> <a href="#cite_ref-Pompilio_2015_6-1">b</a> <a href="#cite_ref-Pompilio_2015_6-2">c</a> <a href="#cite_ref-Pompilio_2015_6-3">d</a> <a href="#cite_ref-Pompilio_2015_6-4">e</a> <a href="#cite_ref-Pompilio_2015_6-5">f</a> <a href="#cite_ref-Pompilio_2015_6-6">g</a> <a href="#cite_ref-Pompilio_2015_6-7">h</a> <a href="#cite_ref-Pompilio_2015_6-8">i</a> <cite id="CITEREFPompilioDe_NicolaCrocettaGuarnieri2015" class="citation journal cs1">Pompilio A, De Nicola S, Crocetta V, Guarnieri S, Savini V, Carretto E, Di Bonaventura G (May 2015). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4440327">"New insights in Staphylococcus pseudintermedius pathogenicity: antibiotic-resistant biofilm formation by a human wound-associated strain"</a>. BMC Microbiology. 15: 109. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1186%2Fs12866-015-0449-x">10.1186/s12866-015-0449-x</a>. <a href="PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4440327">4440327</a>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/25994406">25994406</a>.</cite>

</li>

<li id="cite_note-Garbacz_2013-7">^ <a href="#cite_ref-Garbacz_2013_7-0">a</a> <a href="#cite_ref-Garbacz_2013_7-1">b</a> <a href="#cite_ref-Garbacz_2013_7-2">c</a> <a href="#cite_ref-Garbacz_2013_7-3">d</a> <a href="#cite_ref-Garbacz_2013_7-4">e</a> <a href="#cite_ref-Garbacz_2013_7-5">f</a> <a href="#cite_ref-Garbacz_2013_7-6">g</a> <a href="#cite_ref-Garbacz_2013_7-7">h</a> <a href="#cite_ref-Garbacz_2013_7-8">i</a> <a href="#cite_ref-Garbacz_2013_7-9">j</a> <a href="#cite_ref-Garbacz_2013_7-10">k</a> <cite id="CITEREFGarbaczZarnowskaPiechowiczHaras2013" class="citation journal cs1">Garbacz K, Zarnowska S, Piechowicz L, Haras K (April 2013). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3711984">"Pathogenicity potential of Staphylococcus pseudintermedius strains isolated from canine carriers and from dogs with infection signs"</a>. Virulence. 4 (3): 255–9. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.4161%2Fviru.23526">10.4161/viru.23526</a>. <a href="PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3711984">3711984</a>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/23328490">23328490</a>.</cite>

</li>

<li id="cite_note-Becker_2011-8">^ <a href="#cite_ref-Becker_2011_8-0">a</a> <a href="#cite_ref-Becker_2011_8-1">b</a> <a href="#cite_ref-Becker_2011_8-2">c</a> <a href="#cite_ref-Becker_2011_8-3">d</a> <a href="#cite_ref-Becker_2011_8-4">e</a> <a href="#cite_ref-Becker_2011_8-5">f</a> <a href="#cite_ref-Becker_2011_8-6">g</a> <a href="#cite_ref-Becker_2011_8-7">h</a> <a href="#cite_ref-Becker_2011_8-8">i</a> <cite id="CITEREFBeckervon_Eiff2011" class="citation book cs1">Becker K, von Eiff C (2011-01-01). "Staphylococcus, Micrococcus, and Other Catalase-Positive Cocci". Manual of Clinical Microbiology, 10th Edition. American Society of Microbiology. pp. 308–330. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1128%2F9781555816728.ch19">10.1128/9781555816728.ch19</a>. <a href="ISBN_(identifier)" class="mw-redirect" title="ISBN (identifier)">ISBN</a> <bdi>978-1-55581-463-2</bdi>.</cite>

</li>

<li id="cite_note-Decristophoris_2011-9">^ <a href="#cite_ref-Decristophoris_2011_9-0">a</a> <a href="#cite_ref-Decristophoris_2011_9-1">b</a> <a href="#cite_ref-Decristophoris_2011_9-2">c</a> <a href="#cite_ref-Decristophoris_2011_9-3">d</a> <cite id="CITEREFDecristophorisFasolaBenagliTonolla2011" class="citation journal cs1">Decristophoris P, Fasola A, Benagli C, Tonolla M, Petrini O (February 2011). "Identification of Staphylococcus intermedius Group by MALDI-TOF MS". Systematic and Applied Microbiology. 34 (1): 45–51. <a href="Bibcode_(identifier)" class="mw-redirect" title="Bibcode (identifier)">Bibcode</a>:<a rel="nofollow" class="external text" href="https://ui.adsabs.harvard.edu/abs/2011SyApM..34...45D">2011SyApM..34...45D</a>. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.syapm.2010.11.004">10.1016/j.syapm.2010.11.004</a>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/21300509">21300509</a>.</cite>

</li>

<li id="cite_note-Murugaiyan_2014-10">^ <a href="#cite_ref-Murugaiyan_2014_10-0">a</a> <a href="#cite_ref-Murugaiyan_2014_10-1">b</a> <a href="#cite_ref-Murugaiyan_2014_10-2">c</a> <cite id="CITEREFMurugaiyanWaltherStammAbou-Elnaga2014" class="citation journal cs1">Murugaiyan J, Walther B, Stamm I, Abou-Elnaga Y, Brueggemann-Schwarze S, Vincze S, et al. (October 2014). <a rel="nofollow" class="external text" href="https://doi.org/10.1111%2F1469-0691.12662">"Species differentiation within the Staphylococcus intermedius group using a refined MALDI-TOF MS database"</a>. Clinical Microbiology and Infection. 20 (10): 1007–15. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1111%2F1469-0691.12662">10.1111/1469-0691.12662</a>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/24807701">24807701</a>.</cite>

</li>

<li id="cite_note-11"><a href="#cite_ref-11">^</a> <cite id="CITEREFStrommengerLayerWerner2018" class="citation book cs1">Strommenger B, Layer F, Werner G (2018). "Staphylococcus aureus and Methicillin-Resistant Staphylococcus aureus in Workers in the Food Industry". Staphylococcus aureus. Elsevier. pp. 163–188. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fb978-0-12-809671-0.00009-7">10.1016/b978-0-12-809671-0.00009-7</a>. <a href="ISBN_(identifier)" class="mw-redirect" title="ISBN (identifier)">ISBN</a> <bdi>978-0-12-809671-0</bdi>. <a href="PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7150186">7150186</a>. <a href="S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:90495265">90495265</a>.</cite>

</li>

<li id="cite_note-Chanchaithong_175–181-12">^ <a href="#cite_ref-Chanchaithong_175–181_12-0">a</a> <a href="#cite_ref-Chanchaithong_175–181_12-1">b</a> <cite id="CITEREFChanchaithongPrapasarakul2011" class="citation journal cs1">Chanchaithong P, Prapasarakul N (August 2011). "Biochemical markers and protein pattern analysis for canine coagulase-positive staphylococci and their distribution on dog skin". Journal of Microbiological Methods. 86 (2): 175–81. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.mimet.2011.04.019">10.1016/j.mimet.2011.04.019</a>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/21586304">21586304</a>.</cite>

</li>

<li id="cite_note-Sasaki_2007-13">^ <a href="#cite_ref-Sasaki_2007_13-0">a</a> <a href="#cite_ref-Sasaki_2007_13-1">b</a> <a href="#cite_ref-Sasaki_2007_13-2">c</a> <a href="#cite_ref-Sasaki_2007_13-3">d</a> <a href="#cite_ref-Sasaki_2007_13-4">e</a> <cite id="CITEREFSasakiKikuchiTanakaTakahashi2007" class="citation journal cs1">Sasaki T, Kikuchi K, Tanaka Y, Takahashi N, Kamata S, Hiramatsu K (September 2007). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2045239">"Reclassification of phenotypically identified staphylococcus intermedius strains"</a>. Journal of Clinical Microbiology. 45 (9): 2770–8. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1128%2FJCM.00360-07">10.1128/JCM.00360-07</a>. <a href="PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2045239">2045239</a>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/17596353">17596353</a>.</cite>

</li>

<li id="cite_note-Bond_2012-14">^ <a href="#cite_ref-Bond_2012_14-0">a</a> <a href="#cite_ref-Bond_2012_14-1">b</a> <a href="#cite_ref-Bond_2012_14-2">c</a> <cite id="CITEREFBondLoeffler2012" class="citation journal cs1">Bond R, Loeffler A (March 2012). <a rel="nofollow" class="external text" href="http://researchonline.rvc.ac.uk/id/eprint/5764/">"What's happened to Staphylococcus intermedius? Taxonomic revision and emergence of multi-drug resistance"</a>. The Journal of Small Animal Practice. 53 (3): 147–54. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1111%2Fj.1748-5827.2011.01165.x">10.1111/j.1748-5827.2011.01165.x</a>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/22251285">22251285</a>.</cite>

</li>

<li id="cite_note-Devriese_2005-15">^ <a href="#cite_ref-Devriese_2005_15-0">a</a> <a href="#cite_ref-Devriese_2005_15-1">b</a> <cite id="CITEREFDevrieseVancanneytBaeleVaneechoutte2005" class="citation journal cs1">Devriese LA, Vancanneyt M, Baele M, Vaneechoutte M, De Graef E, Snauwaert C, et al. (July 2005). <a rel="nofollow" class="external text" href="https://doi.org/10.1099%2Fijs.0.63413-0">"Staphylococcus pseudintermedius sp. nov., a coagulase-positive species from animals"</a>. International Journal of Systematic and Evolutionary Microbiology. 55 (Pt 4): 1569–1573. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1099%2Fijs.0.63413-0">10.1099/ijs.0.63413-0</a>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/16014483">16014483</a>.</cite>

</li>

<li id="cite_note-16"><a href="#cite_ref-16">^</a> <cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/nuccore/AJ780976.1">"Staphylococcus pseudintermedius 16S rRNA gene, type strain LMG 22219T"</a>. 2005-08-15.</cite>

</li>

<li id="cite_note-17"><a href="#cite_ref-17">^</a> <cite class="citation journal cs1"><a rel="nofollow" class="external text" href="https://doi.org/10.1099%2Fijs.0.63740-0">"Notification that new names and new combinations have appeared in volume 55, part 1, of the IJSEM"</a>. International Journal of Systematic and Evolutionary Microbiology. 55 (Pt 3): 987–991. May 2005. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1099%2Fijs.0.63740-0">10.1099/ijs.0.63740-0</a>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/15879222">15879222</a>.</cite>

</li>

<li id="cite_note-18"><a href="#cite_ref-18">^</a> <cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://lpsn.dsmz.de/species/staphylococcus-pseudintermedius">"Species: Staphylococcus pseudintermedius"</a>. lpsn.dsmz.de. Retrieved 2020-11-29.</cite>

</li>

<li id="cite_note-19"><a href="#cite_ref-19">^</a> <cite class="citation web cs1"><a rel="nofollow" class="external text" href="http://www.oxoid.com/uk/blue/prod_detail/prod_detail.asp?pr=CM0145&org=153&c=uk&lang=en#:~:text=Description-,Staphylococcus%20Medium%20No.,mannitol%20fermentation,%20and%20gelatin%20liquefaction">"Oxoid - Product Detail"</a>. www.oxoid.com. Retrieved 2020-11-21.</cite>

</li>

<li id="cite_note-Bannoehr_2012-20">^ <a href="#cite_ref-Bannoehr_2012_20-0">a</a> <a href="#cite_ref-Bannoehr_2012_20-1">b</a> <a href="#cite_ref-Bannoehr_2012_20-2">c</a> <a href="#cite_ref-Bannoehr_2012_20-3">d</a> <a href="#cite_ref-Bannoehr_2012_20-4">e</a> <a href="#cite_ref-Bannoehr_2012_20-5">f</a> <a href="#cite_ref-Bannoehr_2012_20-6">g</a> <a href="#cite_ref-Bannoehr_2012_20-7">h</a> <a href="#cite_ref-Bannoehr_2012_20-8">i</a> <a href="#cite_ref-Bannoehr_2012_20-9">j</a> <a href="#cite_ref-Bannoehr_2012_20-10">k</a> <a href="#cite_ref-Bannoehr_2012_20-11">l</a> <a href="#cite_ref-Bannoehr_2012_20-12">m</a> <a href="#cite_ref-Bannoehr_2012_20-13">n</a> <a href="#cite_ref-Bannoehr_2012_20-14">o</a> <a href="#cite_ref-Bannoehr_2012_20-15">p</a> <a href="#cite_ref-Bannoehr_2012_20-16">q</a> <a href="#cite_ref-Bannoehr_2012_20-17">r</a> <a href="#cite_ref-Bannoehr_2012_20-18">s</a> <a href="#cite_ref-Bannoehr_2012_20-19">t</a> <a href="#cite_ref-Bannoehr_2012_20-20">u</a> <a href="#cite_ref-Bannoehr_2012_20-21">v</a> <a href="#cite_ref-Bannoehr_2012_20-22">w</a> <a href="#cite_ref-Bannoehr_2012_20-23">x</a> <cite id="CITEREFBannoehrGuardabassi2012" class="citation journal cs1">Bannoehr J, Guardabassi L (August 2012). "Staphylococcus pseudintermedius in the dog: taxonomy, diagnostics, ecology, epidemiology and pathogenicity". Veterinary Dermatology. 23 (4): 253–66, e51–2. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1111%2Fj.1365-3164.2012.01046.x">10.1111/j.1365-3164.2012.01046.x</a>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/22515504">22515504</a>.</cite>

</li>

<li id="cite_note-21"><a href="#cite_ref-21">^</a> <cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://asm.org/Articles/2020/February/Identifying-Bacteria-Through-Look,-Growth,-Stain">"Identifying Bacteria Through Look, Growth, Stain and Strain"</a>. ASM.org. 2020-02-07. Retrieved 2023-02-15.</cite>

</li>

<li id="cite_note-22"><a href="#cite_ref-22">^</a> <cite id="CITEREFRausLove1983" class="citation journal cs1">Raus J, Love DN (October 1983). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC270907">"Characterization of coagulase-positive Staphylococcus intermedius and Staphylococcus aureus isolated from veterinary clinical specimens"</a>. Journal of Clinical Microbiology. 18 (4): 789–92. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1128%2FJCM.18.4.789-792.1983">10.1128/JCM.18.4.789-792.1983</a>. <a href="PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC270907">270907</a>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/6630462">6630462</a>.</cite>

</li>

<li id="cite_note-Börjesson_2015-23">^ <a href="#cite_ref-Börjesson_2015_23-0">a</a> <a href="#cite_ref-Börjesson_2015_23-1">b</a> <cite id="CITEREFBörjessonGómez-SanzEkströmTorres2015" class="citation journal cs1">Börjesson S, Gómez-Sanz E, Ekström K, Torres C, Grönlund U (April 2015). "Staphylococcus pseudintermedius can be misdiagnosed as Staphylococcus aureus in humans with dog bite wounds". European Journal of Clinical Microbiology & Infectious Diseases. 34 (4): 839–44. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1007%2Fs10096-014-2300-y">10.1007/s10096-014-2300-y</a>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/25532507">25532507</a>. <a href="S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:13173599">13173599</a>.</cite>

</li>

<li id="cite_note-24"><a href="#cite_ref-24">^</a> <cite id="CITEREFNisaBerckerMidwinterBruce2019" class="citation journal cs1">Nisa S, Bercker C, Midwinter AC, Bruce I, Graham CF, Venter P, et al. (February 2019). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361924">"Combining MALDI-TOF and genomics in the study of methicillin resistant and multidrug resistant Staphylococcus pseudintermedius in New Zealand"</a>. Scientific Reports. 9 (1): 1271. <a href="Bibcode_(identifier)" class="mw-redirect" title="Bibcode (identifier)">Bibcode</a>:<a rel="nofollow" class="external text" href="https://ui.adsabs.harvard.edu/abs/2019NatSR...9.1271N">2019NatSR...9.1271N</a>. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1038%2Fs41598-018-37503-9">10.1038/s41598-018-37503-9</a>. <a href="PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361924">6361924</a>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/30718644">30718644</a>.</cite>

</li>

<li id="cite_note-25"><a href="#cite_ref-25">^</a> <cite id="CITEREFGonzález-DomínguezCarvajalCalle-EcheverriChinchilla-Cárdenas2020" class="citation journal cs1">González-Domínguez MS, Carvajal HD, Calle-Echeverri DA, Chinchilla-Cárdenas D (2020-07-23). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7390895">"Molecular Detection and Characterization of the mecA and nuc Genes From Staphylococcus Species (S. aureus, S. pseudintermedius, and S. schleiferi) Isolated From Dogs Suffering Superficial Pyoderma and Their Antimicrobial Resistance Profiles"</a>. Frontiers in Veterinary Science. 7: 376. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.3389%2Ffvets.2020.00376">10.3389/fvets.2020.00376</a>. <a href="PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7390895">7390895</a>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/32793641">32793641</a>.</cite>

</li>

<li id="cite_note-26"><a href="#cite_ref-26">^</a> <cite id="CITEREFWuBurnhamWestbladeDien_Bard2016" class="citation journal cs1">Wu MT, Burnham CA, Westblade LF, Dien Bard J, Lawhon SD, Wallace MA, et al. (March 2016). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4767974">"Evaluation of Oxacillin and Cefoxitin Disk and MIC Breakpoints for Prediction of Methicillin Resistance in Human and Veterinary Isolates of Staphylococcus intermedius Group"</a>. Journal of Clinical Microbiology. 54 (3): 535–42. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1128%2FJCM.02864-15">10.1128/JCM.02864-15</a>. <a href="PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4767974">4767974</a>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/26607988">26607988</a>.</cite>

</li>

<li id="cite_note-27"><a href="#cite_ref-27">^</a> <cite class="citation journal cs1">"Vitek 2 Antimicrobial Susceptibility Testing". Biomedical Safety & Standards. 49 (4): 28. 2019. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1097%2F01.bmsas.0000553632.43991.10">10.1097/01.bmsas.0000553632.43991.10</a>. <a href="S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:243674809">243674809</a>.</cite>

</li>

<li id="cite_note-28"><a href="#cite_ref-28">^</a> <cite id="CITEREFJones1984" class="citation journal cs1">Jones RN (1984). "NCCLS guidelines: revised performance standards for antimicrobial disk susceptibility tests". Antimicrobic Newsletter. 1 (8): 64–65. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2F0738-1751%2884%2990027-3">10.1016/0738-1751(84)90027-3</a>.</cite>

</li>

<li id="cite_note-29"><a href="#cite_ref-29">^</a> <cite id="CITEREFDavisJacksonFedorka-CrayBarrett2014" class="citation journal cs1">Davis JA, Jackson CR, Fedorka-Cray PJ, Barrett JB, Brousse JH, Gustafson J, Kucher M (July 2014). "Carriage of methicillin-resistant staphylococci by healthy companion animals in the US". Letters in Applied Microbiology. 59 (1): 1–8. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1111%2Flam.12254">10.1111/lam.12254</a>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/24730724">24730724</a>. <a href="S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:31682652">31682652</a>.</cite>

</li>

<li id="cite_note-Somayaji_2016-30">^ <a href="#cite_ref-Somayaji_2016_30-0">a</a> <a href="#cite_ref-Somayaji_2016_30-1">b</a> <a href="#cite_ref-Somayaji_2016_30-2">c</a> <a href="#cite_ref-Somayaji_2016_30-3">d</a> <cite id="CITEREFSomayajiRubinPriyanthaChurch2016" class="citation journal cs1">Somayaji R, Rubin JE, Priyantha MA, Church D (October 2016). <a rel="nofollow" class="external text" href="https://doi.org/10.2217%2Ffmb-2016-0137">"Exploring Staphylococcus pseudintermedius: an emerging zoonotic pathogen?"</a>. Future Microbiology. 11 (11): 1371–1374. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.2217%2Ffmb-2016-0137">10.2217/fmb-2016-0137</a>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/27750440">27750440</a>.</cite>

</li>

<li id="cite_note-Gagetti_2019-31">^ <a href="#cite_ref-Gagetti_2019_31-0">a</a> <a href="#cite_ref-Gagetti_2019_31-1">b</a> <a href="#cite_ref-Gagetti_2019_31-2">c</a> <cite id="CITEREFGagettiWattamGiacoboniDe_Paulis2019" class="citation journal cs1">Gagetti P, Wattam AR, Giacoboni G, De Paulis A, Bertona E, Corso A, Rosato AE (July 2019). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6660709">"Identification and molecular epidemiology of methicillin resistant Staphylococcus pseudintermedius strains isolated from canine clinical samples in Argentina"</a>. BMC Veterinary Research. 15 (1): 264. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1186%2Fs12917-019-1990-x">10.1186/s12917-019-1990-x</a>. <a href="PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6660709">6660709</a>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/31351494">31351494</a>.</cite>

</li>

<li id="cite_note-32"><a href="#cite_ref-32">^</a> <cite id="CITEREFCoutoMonchiqueBelasMarques2016" class="citation journal cs1">Couto N, Monchique C, Belas A, Marques C, Gama LT, Pomba C (June 2016). <a rel="nofollow" class="external text" href="https://doi.org/10.1093%2Fjac%2Fdkw029">"Trends and molecular mechanisms of antimicrobial resistance in clinical staphylococci isolated from companion animals over a 16 year period"</a>. The Journal of Antimicrobial Chemotherapy. 71 (6): 1479–87. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1093%2Fjac%2Fdkw029">10.1093/jac/dkw029</a>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/26944924">26944924</a>.</cite>

</li>

<li id="cite_note-33"><a href="#cite_ref-33">^</a> <cite id="CITEREFKadlecSchwarzPerretenAndersson2010" class="citation journal cs1">Kadlec K, Schwarz S, Perreten V, Andersson UG, Finn M, Greko C, et al. (August 2010). <a rel="nofollow" class="external text" href="https://doi.org/10.1093%2Fjac%2Fdkq203">"Molecular analysis of methicillin-resistant Staphylococcus pseudintermedius of feline origin from different European countries and North America"</a>. The Journal of Antimicrobial Chemotherapy. 65 (8): 1826–8. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1093%2Fjac%2Fdkq203">10.1093/jac/dkq203</a>. <a href="Hdl_(identifier)" class="mw-redirect" title="Hdl (identifier)">hdl</a>:<a rel="nofollow" class="external text" href="https://hdl.handle.net/20.500.11820%2Fcbd3237d-b913-42c7-9987-ecc4e95cde02">20.500.11820/cbd3237d-b913-42c7-9987-ecc4e95cde02</a>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/20534627">20534627</a>.</cite>

</li>

<li id="cite_note-Eckholm_2013-34">^ <a href="#cite_ref-Eckholm_2013_34-0">a</a> <a href="#cite_ref-Eckholm_2013_34-1">b</a> <cite id="CITEREFEckholmOuterbridgeWhiteSykes2013" class="citation journal cs1">Eckholm NG, Outerbridge CA, White SD, Sykes JE (February 2013). "Prevalence of and risk factors for isolation of meticillin-resistant Staphylococcus spp. from dogs with pyoderma in northern California, USA". Veterinary Dermatology. 24 (1): 154–61.e34. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1111%2Fj.1365-3164.2012.01051.x">10.1111/j.1365-3164.2012.01051.x</a>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/23331692">23331692</a>.</cite>

</li>

<li id="cite_note-pmid21721415-35"><a href="#cite_ref-pmid21721415_35-0">^</a> <cite id="CITEREFGarbaczPiechowiczZarnowskaHaras2011" class="citation journal cs1">Garbacz K, Piechowicz L, Zarnowska S, Haras K, Dabrowska-Szponar M (2011). <a rel="nofollow" class="external text" href="https://doi.org/10.2478%2Fv10181-011-0043-6">"Heterogeneity of methicillin-sensitive Staphylococcus pseudintermedius strains isolated from diseased dogs"</a>. Polish Journal of Veterinary Sciences. 14 (2): 283–4. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.2478%2Fv10181-011-0043-6">10.2478/v10181-011-0043-6</a>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/21721415">21721415</a>.</cite>

</li>

<li id="cite_note-36"><a href="#cite_ref-36">^</a> <cite id="CITEREFOslandVestbyFanuelsenSlettemeås2012" class="citation journal cs1">Osland AM, Vestby LK, Fanuelsen H, Slettemeås JS, Sunde M (April 2012). <a rel="nofollow" class="external text" href="https://doi.org/10.1093%2Fjac%2Fdkr576">"Clonal diversity and biofilm-forming ability of methicillin-resistant Staphylococcus pseudintermedius"</a>. The Journal of Antimicrobial Chemotherapy. 67 (4): 841–8. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1093%2Fjac%2Fdkr576">10.1093/jac/dkr576</a>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/22258925">22258925</a>.</cite>

</li>

<li id="cite_note-Yarbrough_2018-37">^ <a href="#cite_ref-Yarbrough_2018_37-0">a</a> <a href="#cite_ref-Yarbrough_2018_37-1">b</a> <cite id="CITEREFYarbroughLainhartBurnham2018" class="citation journal cs1">Yarbrough ML, Lainhart W, Burnham CA (March 2018). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5824035">"Epidemiology, Clinical Characteristics, and Antimicrobial Susceptibility Profiles of Human Clinical Isolates of Staphylococcus intermedius Group"</a>. Journal of Clinical Microbiology. 56 (3). <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1128%2FJCM.01788-17">10.1128/JCM.01788-17</a>. <a href="PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5824035">5824035</a>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/29305548">29305548</a>.</cite>

</li>

<li id="cite_note-Kmieciak_2018-38">^ <a href="#cite_ref-Kmieciak_2018_38-0">a</a> <a href="#cite_ref-Kmieciak_2018_38-1">b</a> <cite id="CITEREFKmieciakSzewczyk2018" class="citation journal cs1">Kmieciak W, Szewczyk EM (November 2018). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6182621">"Are zoonotic Staphylococcus pseudintermedius strains a growing threat for humans?"</a>. Folia Microbiologica. 63 (6): 743–747. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1007%2Fs12223-018-0615-2">10.1007/s12223-018-0615-2</a>. <a href="PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6182621">6182621</a>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/29804274">29804274</a>.</cite>

</li>

<li id="cite_note-Bajwa_2016-39">^ <a href="#cite_ref-Bajwa_2016_39-0">a</a> <a href="#cite_ref-Bajwa_2016_39-1">b</a> <cite id="CITEREFBajwa2016" class="citation journal cs1">Bajwa J (February 2016). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4713004">"Canine superficial pyoderma and therapeutic considerations"</a>. The Canadian Veterinary Journal. 57 (2): 204–6. <a href="PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4713004">4713004</a>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/26834275">26834275</a>.</cite>

</li>

<li id="cite_note-Fitzgerald_2009-40">^ <a href="#cite_ref-Fitzgerald_2009_40-0">a</a> <a href="#cite_ref-Fitzgerald_2009_40-1">b</a> <a href="#cite_ref-Fitzgerald_2009_40-2">c</a> <a href="#cite_ref-Fitzgerald_2009_40-3">d</a> <a href="#cite_ref-Fitzgerald_2009_40-4">e</a> <cite id="CITEREFFitzgerald2009" class="citation journal cs1">Fitzgerald JR (October 2009). "The Staphylococcus intermedius group of bacterial pathogens: species re-classification, pathogenesis and the emergence of meticillin resistance". Veterinary Dermatology. 20 (5–6): 490–5. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1111%2Fj.1365-3164.2009.00828.x">10.1111/j.1365-3164.2009.00828.x</a>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/20178486">20178486</a>.</cite>

</li>

<li id="cite_note-Starlander_2014-41">^ <a href="#cite_ref-Starlander_2014_41-0">a</a> <a href="#cite_ref-Starlander_2014_41-1">b</a> <cite id="CITEREFStarlanderBörjessonGrönlund-AnderssonTellgren-Roth2014" class="citation journal cs1">Starlander G, Börjesson S, Grönlund-Andersson U, Tellgren-Roth C, Melhus A (August 2014). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4136194">"Cluster of infections caused by methicillin-resistant Staphylococcus pseudintermedius in humans in a tertiary hospital"</a>. Journal of Clinical Microbiology. 52 (8): 3118–20. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1128%2FJCM.00703-14">10.1128/JCM.00703-14</a>. <a href="PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4136194">4136194</a>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/24871217">24871217</a>.</cite>

</li>

<li id="cite_note-Stegmann_2010-42">^ <a href="#cite_ref-Stegmann_2010_42-0">a</a> <a href="#cite_ref-Stegmann_2010_42-1">b</a> <a href="#cite_ref-Stegmann_2010_42-2">c</a> <a href="#cite_ref-Stegmann_2010_42-3">d</a> <cite id="CITEREFStegmannBurnensMarantaPerreten2010" class="citation journal cs1">Stegmann R, Burnens A, Maranta CA, Perreten V (September 2010). <a rel="nofollow" class="external text" href="https://doi.org/10.1093%2Fjac%2Fdkq241">"Human infection associated with methicillin-resistant Staphylococcus pseudintermedius ST71"</a>. The Journal of Antimicrobial Chemotherapy. 65 (9): 2047–8. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1093%2Fjac%2Fdkq241">10.1093/jac/dkq241</a>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/20601356">20601356</a>.</cite>

</li>

<li id="cite_note-Merck_Manual-43">^ <a href="#cite_ref-Merck_Manual_43-0">a</a> <a href="#cite_ref-Merck_Manual_43-1">b</a> <a href="#cite_ref-Merck_Manual_43-2">c</a> <cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.merckmanuals.com/professional/infectious-diseases/gram-positive-cocci/staphylococcal-infections">"Staphylococcal Infections - Infectious Diseases"</a>. Merck Manuals Professional Edition. Retrieved 2020-10-06.</cite>

</li>

<li id="cite_note-Paul_2011-44">^ <a href="#cite_ref-Paul_2011_44-0">a</a> <a href="#cite_ref-Paul_2011_44-1">b</a> <cite id="CITEREFPaulMoodleyGhibaudoGuardabassi2011" class="citation journal cs1">Paul NC, Moodley A, Ghibaudo G, Guardabassi L (December 2011). "Carriage of methicillin-resistant Staphylococcus pseudintermedius in small animal veterinarians: indirect evidence of zoonotic transmission". Zoonoses and Public Health. 58 (8): 533–9. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1111%2Fj.1863-2378.2011.01398.x">10.1111/j.1863-2378.2011.01398.x</a>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/21824350">21824350</a>. <a href="S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:36452642">36452642</a>.</cite>

</li>

</ol></div>

<div class="mw-heading mw-heading2"><h2 id="Further_reading">Further reading</h2></div>

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<ul><li><cite id="CITEREFWindahlReimegårdHolstEgenvall2012" class="citation journal cs1">Windahl U, Reimegård E, Holst BS, Egenvall A, Fernström L, Fredriksson M, et al. (March 2012). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3325892">"Carriage of methicillin-resistant Staphylococcus pseudintermedius in dogs--a longitudinal study"</a>. BMC Veterinary Research. 8 (1): 34. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1186%2F1746-6148-8-34">10.1186/1746-6148-8-34</a>. <a href="PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3325892">3325892</a>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/22444911">22444911</a>.</cite></li>

<li><cite id="CITEREFHimsworthPatrickParsonsFeng2013" class="citation journal cs1">Himsworth CG, Patrick DM, Parsons K, Feng A, Weese JS (January 2013). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3557998">"Methicillin-resistant Staphylococcus pseudintermedius in rats"</a>. Emerging Infectious Diseases. 19 (1): 169–70. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.3201%2Feid1901.120897">10.3201/eid1901.120897</a>. <a href="PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3557998">3557998</a>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/23260061">23260061</a>.</cite></li></ul>

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<div class="mw-heading mw-heading2"><h2 id="External_links">External links</h2></div>

<ul><li><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://web.archive.org/web/20230000000000/http://www.eol.org/pages/975962">"Staphylococcus pseudintermedius"</a>. The <a href="Encyclopedia_of_Life" title="Encyclopedia of Life">Encyclopedia of Life</a>.</cite> </li>

<li><a rel="nofollow" class="external text" href="http://bacdive.dsmz.de/index.php?search=14670&submit=Search">Type strain of Staphylococcus pseudintermedius at BacDive - the Bacterial Diversity Metadatabase</a></li></ul>

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</style></div><div role="navigation" class="navbox" aria-labelledby="Taxon_identifiers1641" style="padding:3px"><table class="nowraplinks hlist navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><div id="Taxon_identifiers1641" style="font-size:114%;margin:0 4em">Taxon identifiers</div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align: left;">Staphylococcus pseudintermedius</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Wikidata" title="Wikidata">Wikidata</a>: <a href="https://www.wikidata.org/wiki/Q16992700" class="extiw external" title="wikidata:Q16992700">Q16992700</a></li>

<li><a href="BacDive" title="BacDive">BacDive</a>: <a rel="nofollow" class="external text" href="https://bacdive.dsmz.de/strain/14670">14670</a></li>

<li><a href="List_of_Prokaryotic_names_with_Standing_in_Nomenclature" title="List of Prokaryotic names with Standing in Nomenclature">LPSN</a>: <a rel="nofollow" class="external text" href="https://lpsn.dsmz.de/species/staphylococcus-pseudintermedius">staphylococcus-pseudintermedius</a></li>

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This article is issued from <a class="external text" title="Last edited on 2025-07-19" href="https://en.wikipedia.org/wiki/?title=Staphylococcus_pseudintermedius&oldid=1301335907">Wikipedia</a>. The text is available under <a class="external text" href="https://creativecommons.org/licenses/by-sa/4.0/deed.en">Creative Commons Attribution-Share Alike 4.0</a> unless otherwise noted. Additional terms may apply for the media files.

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